9-hydroxy-7,7-dimethyl-9$l^{3}-ioda-8-oxabicyclo[4.3.0]nona-1,3,5-trie ne

Base Information

• Chemical Name: 9-hydroxy-7,7-dimethyl-9$l^{3}-ioda-8-oxabicyclo[4.3.0]nona-1,3,5-trie ne
• CAS No.: 69429-70-5
• Molecular Formula: C9H11 I O2
• Molecular Weight: 278.09
• Mol file: 69429-70-5.mol

Synonyms:NSC 312854

Chemical Property of 9-hydroxy-7,7-dimethyl-9$l^{3}-ioda-8-oxabicyclo[4.3.0]nona-1,3,5-trie ne

Chemical Property:

• PSA: 29.46000
• LogP: 2.83040
• Storage Temp.: 2-8°C

Purity/Quality:

1,3-Dihydro-1-hydroxy-3,3-dimethyl-1,2-benziodoxole ≥99%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-hydroxy-7,7-dimethyl-9$l^{3}-ioda-8-oxabicyclo[4.3.0]nona-1,3,5-trie ne

There total 4 articles about 9-hydroxy-7,7-dimethyl-9$l^{3}-ioda-8-oxabicyclo[4.3.0]nona-1,3,5-trie ne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-bromo-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole (69352-03-0) → 1-hydroxy-3,3-dimethyl-1,3-dihydro-λ3-benzo[d][1,2]iodoxole (69429-70-5)

Guidance literature:

With potassium hydroxide; In dichloromethane; at 20 ℃;

DOI:10.1039/c3cc44792h

Reference yield: 59.0%

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole (69352-04-1) → 1-hydroxy-3,3-dimethyl-1,3-dihydro-λ3-benzo[d][1,2]iodoxole (69429-70-5)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; for 3h;

DOI:10.1002/adsc.201300266

Reference yield:

2-(2-iodophenyl)propan-2-ol (69352-05-2) → 1-hydroxy-3,3-dimethyl-1,3-dihydro-λ3-benzo[d][1,2]iodoxole (69429-70-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 56.5 percent / tert-butyl hypochlorite / CCl₄ / 0.5 h

2: 53 percent / aq. KOH / CH₂Cl₂ / 0.33 h

With potassium hydroxide; tert-butylhypochlorite; In tetrachloromethane; dichloromethane;

DOI:10.1021/ja00183a038

upstream raw materials:

1-chloro-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole

o-iodo-methyl-benzoic acid

2-(2-iodophenyl)propan-2-ol

1-bromo-3,3-dimethyl-1,3-dihydro-1λ³-benzo[d][1,2]iodaoxole

Downstream raw materials:

1-fluoro-3,3-dimethyl-1,3-dihydro-1λ³-benzo[d][1,2]iodaoxole