4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester
• CAS No.: 121767-34-8
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 121767-34-8.mol

Synonyms:4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester

Chemical Property of 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester

There total 3 articles about 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

crotonic acid methyl ester (623-43-8) + C13H19NOSi (153373-76-3) → 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester (121767-34-8)

Guidance literature:

crotonic acid methyl ester; C₁₃H₁₉NOSi; In toluene; at 110 ℃; for 12h; Inert atmosphere;

With methanol; In toluene; for 0.5h;

DOI:10.1002/anie.200806065

Reference yield:

N-benzylidene-1,1,1-trimethylsilanamine (17599-61-0) → 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester (121767-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / Et₃N

2: 2.) MeOH / 1.) toluene, 110 deg C, 24 h

With methanol; triethylamine;

DOI:10.1016/S0040-4039(00)82280-7

Reference yield:

benzaldehyde (100-52-7) → 4,5-dimethyl-6-oxo-2-phenyl-piperidine-3-carboxylic acid methyl ester (121767-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / Me₃SiCl

2: 60 percent / Et₃N

3: 2.) MeOH / 1.) toluene, 110 deg C, 24 h

With methanol; chloro-trimethyl-silane; triethylamine;

DOI:10.1016/S0040-4039(00)82280-7

upstream raw materials:

N-benzylidene-1,1,1-trimethylsilanamine

benzaldehyde

crotonic acid methyl ester

C₁₃H₁₉NOSi