1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

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Chemical Name:1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one
CAS No.:1401731-36-9
Molecular Formula:C₂₁H₁₉N₇O
Molecular Weight:385.428
Hs Code.:

Synonyms:1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

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Chemical Property of 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

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Technology Process of 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

There total 7 articles about 1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401732-44-2
1-(3-((6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

: 1401731-36-9
1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

Guidance literature:: 1-(3-((6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one; With trifluoroacetic acid; In chloroform; at 50 ℃;

With water; pH=8;

Reference yield:

: 31992-43-5
1-(3-aminophenyl)pyrrolidin-2-one

: 1401731-36-9
1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C / Inert atmosphere; Sealed tube

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere; Sealed tube

3.1: trifluoroacetic acid / chloroform / 50 °C

3.2: pH 8

With caesium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; chloroform; water; toluene;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401731-36-9
1-(3-((6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)amino)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 90 °C / Inert atmosphere

5.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 100 °C / Inert atmosphere; Sealed tube

6.1: trifluoroacetic acid / chloroform / 50 °C

6.2: pH 8

With hydrogen bromide; potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; copper(I) bromide; In 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;