erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester

Base Information

• Chemical Name: erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester
• CAS No.: 133421-02-0
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 133421-02-0.mol

Synonyms:erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester

Chemical Property of erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester

There total 6 articles about erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3R)-ethyl 2,3-dihydroxy-3-phenylpropanoate (108741-13-5) + 2,2-dimethoxy-propane (77-76-9) → erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester (133421-02-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃;

Reference yield: 5.0%

2,2-dimethoxy-propane (77-76-9) + ethyl trans-3-phenyl-1-oxirane-2-carboxylate (2272-55-1) → (2S,3R)-ethyl 3-phenyloxirane-2-carboxylate (121-39-1,2272-49-3,2272-55-1,54276-44-7,56791-22-1,126060-73-9,130321-77-6,130321-78-7,130605-53-7) + C14H18O4 + C14H18O4 + erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester (133421-02-0)

Guidance literature:

ethyl trans-3-phenyl-1-oxirane-2-carboxylate; In di-isopropyl ether; at 20 ℃; for 72h;

2,2-dimethoxy-propane; With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 12h; Further stages.;

DOI:10.1016/j.tetasy.2008.01.036

Reference yield:

3-(Dimethylthexylsiloxy)-3-phenyl-2-(trimethylsiloxy)propannitril (133421-01-9,133445-42-8) → erythro-2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonsaeure-ethylester (133421-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: conc.HCl / ethanol / 96 h / Ambient temperature

2: conc.H₂SO₄, HC(OEt)3 / 48 h / Ambient temperature

3: HC(OEt)3 / 24 h / Ambient temperature

With hydrogenchloride; sulfuric acid; orthoformic acid triethyl ester; In ethanol;

upstream raw materials:

ethyl (3R)-2,3-dihydroxy-3-phenylpropanoate

acetone

2,2-dimethoxy-propane

(R)-2,3-Dihydroxy-3-phenyl-propionic acid

Downstream raw materials:

((4S,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)methanol

[1-((4S,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine