(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

Base Information

Chemical Name:(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester
CAS No.:1257265-62-5
Molecular Formula:C₂₈H₂₉F₂NO₄
Molecular Weight:481.539
Hs Code.:

Synonyms:(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

Suppliers and Price of (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

Chemical Property:

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Technology Process of (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

There total 3 articles about (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

: 319-60-8
3,5-difluoro-4-methoxybenzoic acid

: 1257265-62-5
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

Guidance literature:: With triethylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: (2R,4S)-4-amino-5-biphenyl-4-yl-2-methyl-pentanoic acid ethyl ester hydrochloride salt

: 319-60-8
3,5-difluoro-4-methoxybenzoic acid

: 1257265-62-5
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

Guidance literature:: With triethanolamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;