(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

Base Information

Chemical Name:(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid
CAS No.:1257265-61-4
Molecular Formula:C₂₅H₂₃F₂NO₄
Molecular Weight:439.459
Hs Code.:

Synonyms:(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

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Chemical Property of (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

Chemical Property:

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Technology Process of (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

There total 4 articles about (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257265-63-6
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid ethyl ester

: 1257265-61-4
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

Guidance literature:: (2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid ethyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 319-60-8
3,5-difluoro-4-methoxybenzoic acid

: 1257265-61-4
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethanolamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane; ethyl acetate; N,N-dimethyl-formamide

2: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

3: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

With triethanolamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1257265-62-5
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-methoxybenzoylamino)-2-methylpentanoic acid ethyl ester

: 1257265-61-4
(2R,4S)-5-biphenyl-4-yl-4-(3,5-difluoro-4-hydroxybenzoylamino)-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

2: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; methanol

In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;