(11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione

Base Information

Chemical Name:(11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione
CAS No.:96285-40-4
Molecular Formula:C₃₀H₃₇NO₄
Molecular Weight:475.628
Hs Code.:
Mol file:96285-40-4.mol

Synonyms:17α-acetoxy-11β-(4-dimethylaminophenyl)-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Suppliers and Price of (11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(11β,13α)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione
50mg
$ 1320.00

TRC
(11β,13α)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione
5mg
$ 165.00

Total 2 raw suppliers

Chemical Property of (11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(11β,13α)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (11β,13α)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione is a antiprogestational/antiglucocorticoid agent and a progestin and glucocorticord receptor antagonist.

Technology Process of (11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione

There total 6 articles about (11β,13α)-17-(Acetyloxy)-11-[4-(diMethylaMino)phenyl]-19-norpregna-4,9-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 108-24-7
acetic anhydride

: 96285-39-1
11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

: 96285-40-4
17α-acetoxy-11β-(4-dimethylaminophenyl)-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: With dmap; In toluene; for 14h; Ambient temperature;
DOI:10.1016/S0039-128X(84)80027-6

Reference yield:

: 93748-54-0
11β-[4-(dimethylamino)phenyl]-5-hydroxy-5α-estr-9-ene-3,17-dione cyclic 3-(2,2-dimethyl-1,3-propanediyl acetal)

: 96285-40-4
17α-acetoxy-11β-(4-dimethylaminophenyl)-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / dioxane / 0.58 h / 25 °C / Irradiation

2: 80.5 percent / BuLi / tetrahydrofuran / 3 h / Ambient temperature

3: 76.3 percent / aq. acetic acid / 0.5 h / 50 °C

4: 85 percent / HgO, H₂SO₄ / acetic acid / 5 h / 60 °C

5: 93 percent / 4-dimethylaminopyridine / toluene / 14 h / Ambient temperature

With dmap; n-butyllithium; sulfuric acid; mercury(II) oxide; In tetrahydrofuran; 1,4-dioxane; acetic acid; toluene;
DOI:10.1016/S0039-128X(84)80027-6

Reference yield:

: 93748-55-1
11β-(4-dimethylaminophenyl)-3,3-(2,2-dimethyl-trimethylene-1,3-dioxy)-5α-hydroxy-13α-methyl-gon-9-en-17-one

: 96285-40-4
17α-acetoxy-11β-(4-dimethylaminophenyl)-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 80.5 percent / BuLi / tetrahydrofuran / 3 h / Ambient temperature

2: 76.3 percent / aq. acetic acid / 0.5 h / 50 °C

3: 85 percent / HgO, H₂SO₄ / acetic acid / 5 h / 60 °C

4: 93 percent / 4-dimethylaminopyridine / toluene / 14 h / Ambient temperature

With dmap; n-butyllithium; sulfuric acid; mercury(II) oxide; In tetrahydrofuran; acetic acid; toluene;
DOI:10.1016/S0039-128X(84)80027-6