11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Base Information

Chemical Name:11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione
CAS No.:96285-39-1
Molecular Formula:C₂₈H₃₅NO₃
Molecular Weight:433.591
Hs Code.:

Synonyms:11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

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Chemical Property of 11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

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Technology Process of 11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

There total 5 articles about 11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 96346-58-6
11β-(4-dimethylaminophenyl)-17β-ethynyl-17α-hydroxy-13α-methyl-gona-4,9-dien-3-one

: 96285-39-1
11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: With sulfuric acid; mercury(II) oxide; In acetic acid; at 60 ℃; for 5h;
DOI:10.1016/S0039-128X(84)80027-6

Reference yield:

: 93748-54-0
11β-[4-(dimethylamino)phenyl]-5-hydroxy-5α-estr-9-ene-3,17-dione cyclic 3-(2,2-dimethyl-1,3-propanediyl acetal)

: 96285-39-1
11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / dioxane / 0.58 h / 25 °C / Irradiation

2: 80.5 percent / BuLi / tetrahydrofuran / 3 h / Ambient temperature

3: 76.3 percent / aq. acetic acid / 0.5 h / 50 °C

4: 85 percent / HgO, H₂SO₄ / acetic acid / 5 h / 60 °C

With n-butyllithium; sulfuric acid; mercury(II) oxide; In tetrahydrofuran; 1,4-dioxane; acetic acid;
DOI:10.1016/S0039-128X(84)80027-6

Reference yield:

: 93748-55-1
11β-(4-dimethylaminophenyl)-3,3-(2,2-dimethyl-trimethylene-1,3-dioxy)-5α-hydroxy-13α-methyl-gon-9-en-17-one

: 96285-39-1
11β-(4-dimethylaminophenyl)-17α-hydroxy-13α-methyl-18,19-dinor-pregna-4,9-diene-3,20-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 80.5 percent / BuLi / tetrahydrofuran / 3 h / Ambient temperature

2: 76.3 percent / aq. acetic acid / 0.5 h / 50 °C

3: 85 percent / HgO, H₂SO₄ / acetic acid / 5 h / 60 °C

With n-butyllithium; sulfuric acid; mercury(II) oxide; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0039-128X(84)80027-6