(3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester
• CAS No.: 1057694-51-5
• Molecular Formula: C₁₆H₁₆N₂O₃S
• Molecular Weight: 316.381

Synonyms:(3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

Chemical Property of (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

There total 2 articles about (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(3R)-7-methyl-5-oxo-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester (341027-49-4) → (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester (1057694-51-5)

Guidance literature:

(3R)-7-methyl-5-oxo-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester; With oxygen; trifluoroacetic acid; sodium nitrite; In dichloromethane; at 20 ℃;

With acetic acid; zinc; at 20 ℃; for 4h;

DOI:10.1021/ol801506y

Reference yield: 71.0%

→ (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester (1057694-51-5)

Guidance literature:

Reference yield: 85.0%

(3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester (1057694-51-5) → (7R)-6,7-dihydro-4-phenyl-9-oxo-pyrazolo[4,5-d]thiazolo[3,2-a]pyridine-7-carboxylic acid methyl ester (1057694-55-9)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 20 ℃; for 0.5h;

DOI:10.1021/ol801506y

upstream raw materials:

(3R)-7-methyl-5-oxo-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

Downstream raw materials:

(7R)-6,7-dihydro-4-phenyl-9-oxo-pyrazolo[4,5-d]thiazolo[3,2-a]pyridine-7-carboxylic acid methyl ester

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