341027-49-4

Upstream product

• 85920-63-4 5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 341027-48-3 (4R)-2-benzyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester 
• 140-29-4 phenylacetonitrile 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 

Downstream Products

• 341027-43-8 (3R)-6-bromo-7-methyl-5-oxo-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester 
• 341027-45-0 (3R)-6-cyano-7-methyl-5-oxo-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester 
• 1057694-51-5 (3R)-6-amino-2,3-dihydro-7-methyl-5-oxo-8-phenyl-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester 
• 1332324-12-5 (R)-6-formyl-7-methyl-5-oxo-8-phenyl-2,3-dihydro-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester 
• 1332324-14-7 (R)-2,3-dihydro-8,10-diphenyl-5-oxo-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-15-8 (R)-8-(4-cyanophenyl)-2,3-dihydro-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-16-9 (R)-8-(1,3-benzodioxol-5-yl)-2,3-dihydro-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-17-0 (R)-2,3-dihydro-5-oxo-10-phenyl-8-(1-propyl)-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-18-1 (R)-2,3-dihydro-8-isopropyl-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-19-2 (R)-2,3-dihydro-8-(4-methyl-5-imidazolyl)-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-20-5 (R)-2,3-dihydro-8-(3-indolyl)-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-21-6 (R)-2,3-dihydro-8-(2-methyl-6-pyridyl)-5-oxo-10-phenyl-thiazolo[3,2-b][2,7]naphthyridine-3-carboxylic acid methyl ester 
• 1332324-13-6 (R)-2,3-dihydro-8,10-diphenyl-7-(2-hydroxyethyl)-3-methoxycarbonyl-5-oxothiazolo[3,2-b][2,7]naphthyridinium chloride 

Relevant academic research and scientific papers

An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones

Previously, a method for the stereoselective synthesis of β-lactams, starting from 2H-δ2-thiazolines and Meldrum's acid derivatives, has been reported from our laboratory. We now report a new method for the synthesis of optically active, highly substituted ring-fused 2-pyridinones. This was discovered when 2-alkyl-δ2-thiazolines and Meldrum's acid derivatives were treated with HCl(g) in benzene at 5 → 78 °C. Further refinement of the synthetic protocol revealed that use of 1,2-dichloroethane as solvent at 0 → 64 °C led to the desired 2-pyridinones in good yields and with excellent enantioselectivity. Use of these conditions allowed preparation of 2-pyridinones from several different δ2-thiazolines and Meldrum's acid derivatives and may be a general route to 2-pyridinones.

NEW PEPTIDOMIMETIC COMPOUNDS

The present invention relates to new compounds of the formula (I), (II), or (III)wherein R1, R2, R3, R4, R5 and W are as defined herein, and pharmaceutical compositions containing them, and their use