(4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone

Base Information

• Chemical Name: (4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone
• CAS No.: 1009812-43-4
• Molecular Formula: C₁₃H₁₀FIN₂O₃
• Molecular Weight: 388.137
• Mol file: 1009812-43-4.mol

Synonyms:(4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone

Chemical Property of (4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone

There total 1 articles about (4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-fluorobenzoyl chloride (403-43-0) + 6-iodo-2,4-dimethoxypyrimidine (69696-44-2) → (4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone (1009812-43-4)

Guidance literature:

6-iodo-2,4-dimethoxypyrimidine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; at -20 ℃; for 0.25h; Inert atmosphere;

4-fluorobenzoyl chloride; In tetrahydrofuran; at -20 - 25 ℃; for 5h; regioselective reaction; Inert atmosphere;

DOI:10.1039/b812528g

Reference yield:

(4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone (1009812-43-4) + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → 2-[5-(4-fluorobenzoyl)-2,6-dimethoxypyrimidin-4-ylmethyl]acrylic acid ethyl ester (1009812-53-6)

Guidance literature:

(4-fluorophenyl)(4-iodo-2,6-dimethoxypyrimidin-5-yl)methanone; With ethylene dibromide; lithium chloride; zinc; chloro-trimethyl-silane; In tetrahydrofuran; at 25 ℃; for 1h;

ethyl 2-bromomethyl-2-propenoate; In tetrahydrofuran; at 0 ℃; for 1h; Further stages.;

DOI:10.1055/s-2007-983885

upstream raw materials:

4-fluorobenzoyl chloride

6-iodo-2,4-dimethoxypyrimidine

Downstream raw materials:

2-[5-(4-fluorobenzoyl)-2,6-dimethoxypyrimidin-4-ylmethyl]acrylic acid ethyl ester