C₂₁H₂₄BrN₃O₅

Base Information

• Chemical Name: C₂₁H₂₄BrN₃O₅
• CAS No.: 1347720-73-3
• Molecular Formula: C₂₁H₂₄BrN₃O₅
• Molecular Weight: 478.343
• Mol file: 1347720-73-3.mol

Synonyms:C₂₁H₂₄BrN₃O₅

Chemical Property of C₂₁H₂₄BrN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₄BrN₃O₅

There total 9 articles about C₂₁H₂₄BrN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.89%

(2-amino-6-bromophenyl)methanol (861106-92-5) + 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline (183322-18-1) → C21H24BrN3O5 (1347720-73-3)

Guidance literature:

With pyridine; In acetonitrile; for 4h; Reflux;

Reference yield:

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester (179688-26-7) → C21H24BrN3O5 (1347720-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux

2.2: 0.5 h / 20 °C / pH 7 - 8

3.1: pyridine / acetonitrile / 4 h / Reflux

With pyridine; thionyl chloride; ammonium formate; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;

Reference yield:

Ethyl protocatechuate (3943-89-3) → C21H24BrN3O5 (1347720-73-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 6 h / Reflux

2.1: nitric acid / acetic acid / 24 h / 20 °C / cooling with ice-water

3.1: ammonium formate / 5%-palladium/activated carbon / 7 h / 150 °C

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 6 h / Reflux

4.2: 0.5 h / 20 °C / pH 7 - 8

5.1: pyridine / acetonitrile / 4 h / Reflux

With pyridine; thionyl chloride; nitric acid; ammonium formate; potassium carbonate; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In dichloromethane; acetic acid; acetonitrile;

upstream raw materials:

(2-amino-6-bromophenyl)methanol

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

Ethyl protocatechuate

2-nitro-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester