1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Base Information

Chemical Name:1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide
CAS No.:1571134-60-5
Molecular Formula:C₃₁H₂₇F₂N₃O₄S
Molecular Weight:575.636
Hs Code.:

Synonyms:1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

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Chemical Property of 1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Chemical Property:

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Technology Process of 1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

There total 2 articles about 1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 854690-87-2
(3-(difluoromethyl)phenyl)boronic acid

: 1571135-36-8
5-bromo-1-[1-(4-cyanophenyl)ethyl]-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

: 1571134-60-5
1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; acetonitrile; at 75 ℃; for 18h;

Reference yield:

: 1571135-29-9
5-bromo-1-[1-(4-cyanophenyl)ethyl]-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

: 1571134-60-5
1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

1.2: 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile; water / 18 h / 75 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1571134-60-5
1-[1-(4-cyanophenyl)ethyl]-5-(3-(difluoromethyl)phenyl)-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 4-methanesulfonylbenzylamide

: 1571134-62-7
C₃₁H₂₇F₂N₃O₄S

: 1571134-61-6
C₃₁H₂₇F₂N₃O₄S

Guidance literature:: With carbon dioxide; diethylamine; In methanol; at 40 ℃; under 112511 Torr; Resolution of racemate; Supercritical conditions;