2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

Base Information

Chemical Name:2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate
CAS No.:1359029-93-8
Molecular Formula:C₁₇H₁₃F₆N₃O₄S
Molecular Weight:469.364
Hs Code.:

Synonyms:2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

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Chemical Property of 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

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Technology Process of 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

There total 7 articles about 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1359029-95-0
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

: 1359029-93-8
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

Guidance literature:: With triethylamine; In chloroform; at -20 - 20 ℃; for 0.75h; Inert atmosphere;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1359029-93-8
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

4.1: potassium hydroxide; ethanol / 3 h / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

5.2: 10 h / 20 °C / Cooling with ice

6.1: chloroform / 18 h / 80 °C

6.2: 0.5 h

7.1: triethylamine / chloroform / 0.75 h / -20 - 20 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1359029-55-2
ethyl 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylate

: 1359029-93-8
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazole-4-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; ethanol / 3 h / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.2: 10 h / 20 °C / Cooling with ice

3.1: chloroform / 18 h / 80 °C

3.2: 0.5 h

4.1: triethylamine / chloroform / 0.75 h / -20 - 20 °C / Inert atmosphere

With oxalyl dichloride; ethanol; triethylamine; potassium hydroxide; In chloroform; N,N-dimethyl-formamide;