2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

Base Information

Chemical Name:2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one
CAS No.:1359029-95-0
Molecular Formula:C₁₆H₁₄F₃N₃O₂
Molecular Weight:337.301
Hs Code.:

Synonyms:2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

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Chemical Property of 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

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Technology Process of 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

There total 6 articles about 2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 1359029-94-9
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

: 18107-18-1
diazomethyl-trimethyl-silane

: 1359029-95-0
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

Guidance literature:: oxalyl dichloride; 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide; In chloroform; at 80 ℃; for 18h;

diazomethyl-trimethyl-silane; In diethyl ether; chloroform; acetonitrile; for 0.5h;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1359029-95-0
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

4.1: potassium hydroxide; ethanol / 3 h / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

5.2: 10 h / 20 °C / Cooling with ice

6.1: chloroform / 18 h / 80 °C

6.2: 0.5 h

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; potassium hydroxide; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1359029-55-2
ethyl 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylate

: 1359029-95-0
2-(1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1,3-oxazol-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; ethanol / 3 h / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.2: 10 h / 20 °C / Cooling with ice

3.1: chloroform / 18 h / 80 °C

3.2: 0.5 h

With oxalyl dichloride; ethanol; potassium hydroxide; In chloroform; N,N-dimethyl-formamide;