1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

Base Information

Chemical Name:1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone
CAS No.:210992-25-9
Molecular Formula:C₂₂H₂₂ClF₂N₅O
Molecular Weight:445.899
Hs Code.:

Synonyms:1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

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Chemical Property of 1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

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Technology Process of 1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

There total 4 articles about 1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 210992-22-6
4-acetyl-1-(3-chloro-pyridin-2-yl)-5-methylpyrazole

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 180698-14-0
1-(3,5-difluorophenyl)piperazine

: 210992-25-9
1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

Guidance literature:: With hydrogenchloride; In ethanol; for 48h; Heating;
DOI:10.1248/cpb.53.153

Reference yield:

: 210992-22-6
4-acetyl-1-(3-chloro-pyridin-2-yl)-5-methylpyrazole

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 180698-14-0
1-(3,5-difluorophenyl)piperazine

: 210992-25-9
1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

Guidance literature:: With hydrogenchloride; sodium hydrogencarbonate; In ethanol;

Reference yield:

: 33884-41-2
ethoxylideneacetylacetone

: 210992-25-9
1-[1-(3-Chloro-pyridin-2-yl)-5-methyl-4-pyrazolyl]-3-[4-(3,5-difluorophenyl)-1-piperazinyl]-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / ethanol / 1 h / 70 °C

2: 53 percent / HCl / ethanol / 48 h / Heating

With hydrogenchloride; In ethanol; 2: Mannich reaction;
DOI:10.1248/cpb.53.153