methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

Base Information

Chemical Name:methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate
CAS No.:106970-69-8
Molecular Formula:C₂₂H₁₈N₂O₄S
Molecular Weight:406.462
Hs Code.:

Synonyms:methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

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Chemical Property of methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

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Technology Process of methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

There total 6 articles about methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

: 106970-77-8
6-Methyl-4-(3-nitro-phenyl)-3-phenyl-4,7-dihydro-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester

: 106970-69-8
methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: With trifluoroacetic acid; at 20 ℃;
DOI:10.1248/cpb.36.4389

Reference yield: 41.5%

: 67637-83-6
4-phenyl-2-amino-thiophene

: 118431-03-1
methyl 2-E,Z-(3-nitro-phenylmethylen)-3-oxobutanoate

: 120004-41-3
[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-(4-phenyl-thiophen-2-yl)-amine

: 106970-69-8
methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

: 120004-35-5
2-[(5-Amino-3-phenyl-thiophen-2-yl)-(3-nitro-phenyl)-methyl]-3-oxo-butyric acid methyl ester

: 120004-38-8
2-[(3-Nitro-phenyl)-(5-{[1-(3-nitro-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-thiophen-2-yl)-methyl]-3-oxo-butyric acid methyl ester

Guidance literature:: In tert-butyl alcohol; at 80 ℃; Further byproducts given;
DOI:10.1248/cpb.36.4389

Reference yield:

: 54441-66-6
tert-butyl benzoylacetate

: 106970-69-8
methyl 4,7-dihydro-6-methyl-4-(3-nitrophenyl)-3-phenylthieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, acetic acid

2: S, (H₅C₂)2NH

3: 72.8 percent / 2-methyl-propan-2-ol / Heating

4: 80.9 percent / trifluoroacetic acid / 20 °C

With piperidine; acetic acid; diethylamine; trifluoroacetic acid; In tert-butyl alcohol;
DOI:10.1248/cpb.36.4389