54441-66-6

Usage

Uses

Used in Flavoring Agents:
Tert-butyl 3-oxo-3-phenylpropanoate is employed as a flavoring agent in the food and beverage industry, where it imparts a fruity aroma and taste to products. Its use enhances the sensory experience of consumers, making it a valuable addition to a wide range of food and drink items.
Used in Organic Synthesis:
In the field of organic chemistry, tert-butyl 3-oxo-3-phenylpropanoate is used as a reagent in the synthesis of other organic compounds. Its versatility in chemical reactions makes it a useful building block for creating a variety of molecules with different applications.
Used in Research and Development:
Tert-butyl 3-oxo-3-phenylpropanoate is also utilized in research and development settings, where it can be employed to study the properties and reactions of esters. This helps scientists and researchers to better understand the behavior of these compounds and to develop new methods and applications for their use.
Safety Precautions:
It is important to handle tert-butyl 3-oxo-3-phenylpropanoate with care, as it may pose health risks if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken to minimize exposure and ensure the well-being of those working with tert-butyl 3-oxo-3-phenylpropanoate.

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 540-88-5 acetic acid tert-butyl ester 
• 93-99-2 benzoic acid phenyl ester 
• 117356-18-0 β-hydroxy β-phenyl acetate de t-butyle 
• 1694-31-1 tert-butyl acetoacetate 
• 98-88-4 benzoyl chloride 
• 344757-82-0 tert-butyl 2-benzoylacetoacetate 
• 201230-82-2 carbon monoxide 
• 532-27-4 1-chloroacetophenone 
• 75-65-0 tert-butyl alcohol 
• 1207973-75-8 lithium tert-butyl acetate 
• 65-85-0 benzoic acid 
• 34619-03-9 tert-butyldicarbonate 
• 98-86-2 acetophenone 

Downstream Products

• 88460-88-2 1-methyl-6-phenacyl-2-piperidinone 
• 106970-97-2 (E)-4-Cyano-3-phenyl-but-3-enoic acid tert-butyl ester 
• 120834-16-4 2-[1,3]Dithiolan-2-ylidene-3-oxo-3-phenyl-propionic acid tert-butyl ester 
• 120809-26-9 2-[1,3]Dithian-2-ylidene-3-oxo-3-phenyl-propionic acid tert-butyl ester 
• 77092-12-7 6-phenyl-2,2-dimethyl-1,3-dioxin-4-one 
• 53935-56-1 tert-butyl 2,2-dimethyl-3-oxo-3-phenylpropanoate 
• 104015-38-5 tert-butyl 2-benzoylpropionate 
• 219981-44-9 1,1-dimethylethyl α-bromo-β-oxo-benzenepropionate 
• 863643-44-1 2-oxo-1,5-diphenyl-2,3-dihydro-1H-imidazole-4-carboxylic acid 
• 864515-95-7 tert-butyl (3R)-2-benzoyl-3-methyl-5-oxo-5-(2-thioxothiazolidin-3-yl)pentanoate 
• 18735-78-9 2,5-diphenyloxazole-4-carboxylic acid 
• 325968-65-8 2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid 
• 325968-64-7 2-{1-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenyl]-1-methyl-ethyl}-4-phenyl-thiazole-5-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Amide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters

Activated primary, secondary, and tertiary amides were coupled with enolizable esters in the presence of LiHMDS to obtain good yields of β-ketoesters at room temperature. Notably, this protocol provides an efficient, mild, and high chemoselectivity method

Stereodivergent Nucleophilic Additions to Racemic β-Oxo Acid Derivatives: Fast Addition Outcompetes Stereoconvergence in the Archetypal Configurationally Unstable Electrophile

Additions of carbon nucleophiles to racemic α-stereogenic β-oxo acid derivatives that deliver enantiomerically enriched tertiary alcohols are valuable, but uncommon. This article describes stereodivergent Cu-catalyzed borylative cyclizations of racemic β-oxo acid derivatives bearing tethered pro-nucleophilic olefins to deliver highly functionalized cyclopentanols containing four contiguous stereogenic centers. The reported protocol is applicable to a range of β-oxo acid derivatives, and the diastereomeric products are readily isolable by typical chromatographic techniques. α-Stereogenic-β-keto esters are typically thought to have extreme or spontaneous configurational fragility, but mechanistic studies for this system reveal an unusual scenario wherein productive catalysis occurs on the same time scale as background substrate racemization and completely outcompetes on-cycle epimerization, even under the basic conditions of the reaction.

Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes

An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph

Photoredox Catalysis of Aromatic β-Ketoesters for in Situ Production of Transient and Persistent Radicals for Organic Transformation

Radical formation is the initial step for conventional radical chemistry. Reported herein is a unified strategy to generate radicals in situ from aromatic β-ketoesters by using a photocatalyst. Under visible-light irradiation, a small amount of photocatalyst fac-Ir(ppy)3 generates a transient α-carbonyl radical and persistent ketyl radical in situ. In contrast to the well-established approaches, neither stoichiometric external oxidant nor reductant is required for this reaction. The synthetic utility is demonstrated by pinacol coupling of ketyl radicals and benzannulation of α-carbonyl radicals with alkynes to give a series of highly substituted 1-naphthols in good to excellent yields. The readily available photocatalyst, mild reaction conditions, broad substrate scope, and high functional-group tolerance make this reaction a useful synthetic tool.

Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids

Chiral α-chloro-α-fluoro ketones were synthesized by enantio-selective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with modera

PhIO/Et3N ? 3HF-Mediated Formation of Fluorinated 2H-Azirines via Domino Fluorination/Azirination Reaction of Enamines

A variety of enamine carboxylic esters and enaminones were converted to the biologically interesting fluorinated 2H-azirines through reactions with PhIF2 generated in situ by PhIO and Et3N ? 3HF in 1,2-dichroloethane, which features the hypervalent iodine reagents-mediated introduction of fluorine atom and formation of the 2H-azirine skeleton under metal-free conditions. The domino reaction is postulated to proceed via a PhIF2-mediated oxidative fluorination and a subsequent azirination of the fluorinated enamine intermediates. (Figure presented.).

With anti-bacterial activity of the piperidine link 1, 2, 3 - triazole class compound and its preparation method and application

The present invention discloses a piperidine link 1,2,3-triazole compound with antibacterial activity and a preparation method therefor and application thereof, and belongs to the technical field of synthesis of compounds with antibacterial activity. The

Studies of the Electronic Effects of Zinc Cluster Catalysts and Their Application to the Transesterification of β-Keto Esters

The electronic effects of tetranuclear zinc cluster catalysts on transesterification were investigated by changing the carboxylate ligands in the clusters. High catalyst activity crucially depended on the balance between Lewis acidity and Br?nsted basicity of the catalyst; this was consistent with the dual activation of both the electrophile and nucleophile by the cooperative zinc centers. In addition, tetranuclear zinc cluster catalysts achieved the transesterification of β-keto esters with unprecedented levels of broad substrate generality, in which a newly developed pentafluoropropionate-bridged zinc cluster and 4-dimethylaminopyridine additive greatly improved the reactivity of sterically congested α- and α,α-disubstituted β-keto esters. Lewis versus Br?nsted: High catalyst activity of zinc clusters on transesterification crucially depend on a balance between Lewis acidity and Br?nsted basicity of the catalyst. Zinc clusters, including a newly developed pentafluoropropionate-bridged zinc cluster, achieved the transesterification of β-keto esters with unprecedented levels of broad substrate generality (see figure).

RhII-catalyzed [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles

RhII-catalyzed intermolecular [3+2] cycloaddition of 2 H-azirines with N-sulfonyl-1,2,3-triazoles is disclosed, in which a series of fully functionalized pyrroles is produced via rhodium azavinyl carbene intermediates. A distinct feature of this reaction is that the azavinyl carbene serves as a [2 C] equivalent, instead of as [1 C] or aza-[3 C] synthons, which have been reported previously in cyclopropanations and [3 + n] cycloadditions. Moreover, this methodology has also been successfully applied in the total synthesis of URB447 as well as the formal synthesis of Atorvastatin (Lipitor).

Gold-catalyzed synthesis of functionalized pyridines by using 2H-azirines as synthetic equivalents of alkenyl nitrenes

2H-Azirines are easily synthesized from the corresponding ketones and, despite possessing a C=N bond embedded in a strained three-membered cycle, they are sufficiently stable to be isolated, stored, and manipulated. 2H-Azirines can be regarded as valuable