3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole
CAS No.:1201445-42-2
Molecular Formula:C₂₁H₁₄F₃N₃OS
Molecular Weight:413.423
Hs Code.:

Synonyms:3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

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Chemical Property of 3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

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Technology Process of 3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

There total 3 articles about 3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 1034688-73-7
3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

: 1201445-42-2
3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: 3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole; With sodium cyanoborohydride; acetic acid; at 12 - 20 ℃;

With sodium hydroxide;

Reference yield:

: 163797-89-5
N'-hydroxy-1H-indole-5-carboximidamide

: 1201445-42-2
3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

1.2: 16.5 h / 20 - 95 °C

2.1: sodium cyanoborohydride; acetic acid / 12 - 20 °C

With sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;

Reference yield:

: 15861-24-2,142396-06-3
1H-indole-5-carbonitrile

: 1201445-42-2
3-(indolin-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; potassium hydrogencarbonate / ethanol / 16 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

2.2: 16.5 h / 20 - 95 °C

3.1: sodium cyanoborohydride; acetic acid / 12 - 20 °C

With hydroxylamine hydrochloride; sodium cyanoborohydride; benzotriazol-1-ol; potassium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol;