3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole
CAS No.:1034688-73-7
Molecular Formula:C₂₁H₁₂F₃N₃OS
Molecular Weight:411.407
Hs Code.:

Synonyms:3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

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Chemical Property of 3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

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Technology Process of 3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

There total 3 articles about 3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

: 163797-89-5
N'-hydroxy-1H-indole-5-carboximidamide

: 208108-76-3
(4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid

: 1034688-73-7
3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: (4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

N'-hydroxy-1H-indole-5-carboximidamide; In 1,4-dioxane; at 20 - 95 ℃; for 16.5h;

Reference yield:

: 237385-98-7
Methyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate

: 163797-89-5
N-hydroxy-1H-indole-5-carboximidamide

: 1034688-73-7
3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: With sodium ethanolate; In ethanol; at 120 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 15861-24-2,142396-06-3
1H-indole-5-carbonitrile

: 1034688-73-7
3-(1H-indol-5-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; potassium hydrogencarbonate / ethanol / 16 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

2.2: 16.5 h / 20 - 95 °C

With hydroxylamine hydrochloride; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol;