Technology Process of C32H45NO7
There total 2 articles about C32H45NO7 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene;
With
1,2-dibromobutane; iodine; magnesium;
In
tetrahydrofuran;
for 1h;
Reflux;
Inert atmosphere;
C21H29NO4;
cerium(III) chloride;
In
tetrahydrofuran;
at -78 - -35 ℃;
for 6h;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
at -35 ℃;
Product distribution / selectivity;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
1.2: 3 h / -40 - -10 °C / Inert atmosphere
2.1: iodine; magnesium; 1,2-dibromobutane / tetrahydrofuran / 1 h / Reflux; Inert atmosphere
2.2: 6 h / -78 - -35 °C / Inert atmosphere
2.3: -35 °C / Inert atmosphere
With
n-butyllithium; 1,2-dibromobutane; iodine; magnesium; diisopropylamine;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 3 h / 20 °C / 760.05 Torr
2.1: sodium hydrogencarbonate / water; tetrahydrofuran
2.2: 20 °C
3.1: triethylamine; 2-hydroxypyridin / tert-butyl methyl ether / 18 h / 80 °C
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr
4.2: pH 10
With
2-hydroxypyridin; hydrogenchloride; hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; tert-butyl methyl ether; water;
