phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester

Base Information

• Chemical Name: phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester
• CAS No.: 926919-30-4
• Molecular Formula: C₃₃H₃₄F₃O₇P
• Molecular Weight: 630.598
• Mol file: 926919-30-4.mol

Synonyms:phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester

Chemical Property of phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester

There total 5 articles about phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + Phosphoric acid dibenzyl ester (2R,3S)-2,3-bis-benzyloxy-4-oxo-butyl ester (203389-77-9) → phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester (926919-30-4)

Guidance literature:

(trifluoromethyl)trimethylsilane; Phosphoric acid dibenzyl ester (2R,3S)-2,3-bis-benzyloxy-4-oxo-butyl ester; With cesium fluoride;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.11.091

Reference yield:

phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyl ester (926919-29-1) → phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester (926919-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

2.1: 82 percent / PCC; 3 Angstroem molecular sieves / CH₂Cl₂

3.1: cesium fluoride

3.2: 72 percent / tetrabutylammonium fluoride / tetrahydrofuran

With 3 A molecular sieve; tetrabutyl ammonium fluoride; cesium fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.11.091

Reference yield:

(2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol (113350-84-8) → phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-5,5,5-trifluoro-4-hydroxy-pentyl ester (926919-30-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 87 percent / NaH / tetrahydrofuran

2.1: 81 percent / tetrazole; mCPBA / CH₂Cl₂

3.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

4.1: 82 percent / PCC; 3 Angstroem molecular sieves / CH₂Cl₂

5.1: cesium fluoride

5.2: 72 percent / tetrabutylammonium fluoride / tetrahydrofuran

With 1H-tetrazole; 3 A molecular sieve; tetrabutyl ammonium fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.11.091

upstream raw materials:

(trifluoromethyl)trimethylsilane

Phosphoric acid dibenzyl ester (2R,3S)-2,3-bis-benzyloxy-4-oxo-butyl ester

phosphoric acid dibenzyl ester 2,3-bis-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyl ester

(2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol