(4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Base Information

Chemical Name:(4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione
CAS No.:134261-54-4
Molecular Formula:C₁₉H₂₇NO₂Si
Molecular Weight:329.514
Hs Code.:

Synonyms:(4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Suppliers and Price of (4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Chemical Property:

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Technology Process of (4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

There total 17 articles about (4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 134261-53-3
(4aR,8R,8aS)-2-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-8-trimethylsilanyl-3,4,4a,5,8,8a-hexahydro-2H-isoquinolin-1-one

: 134261-54-4
(4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Guidance literature:: With potassium fluoride; In methanol; for 2h; Heating;
DOI:10.1021/jo00015a036

Reference yield:

: 134261-54-4
(4aS,8S,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

: 134261-54-4
(4aR,8R,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Guidance literature:: With sodium methylate; In methanol; Heating;
DOI:10.1021/jo00015a036

Reference yield:

: 58207-98-0
trans-3-(Trimethylsilyl)-2-propensaeure

: 134261-54-4
(4aR,8R,8aR)-2-Benzyl-8-trimethylsilanyl-hexahydro-isoquinoline-1,6-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / oxalyl chloride / CH₂Cl₂ / 2 h / Heating

2: 1) Et₃N / 1) CH₂Cl₂, 0 deg C, 5 min, 2) CH₂Cl₂, warm to r.t.

3: 30percent HCl / tetrahydrofuran / 42 h / Ambient temperature

4: 64 percent / tetrahydrofuran / 14 h / Heating

5: 1) Et₃N / 1) CH₂Cl₂, r.t., 5 min, 2) CH₂Cl₂, 5 min

6: 87 percent / KF*2H₂O / methanol / 2 h / Heating

7: NaOMe / methanol / Heating

With hydrogenchloride; potassium fluoride; oxalyl dichloride; sodium methylate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00015a036