4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

Base Information

Chemical Name:4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride
CAS No.:1207436-33-6
Molecular Formula:C₁₄H₁₉Cl₂NO*ClH
Molecular Weight:324.678
Hs Code.:

Synonyms:4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

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Chemical Property of 4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

Chemical Property:

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Technology Process of 4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

There total 9 articles about 4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1207438-84-3
tert-butyl 4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine-1-carboxylate

: 1207436-33-6
4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

Guidance literature:: With hydrogenchloride; ethanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207436-33-6
4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

3.1: borane-THF / tetrahydrofuran / 20 - 70 °C

4.1: CHIRALPAK AD / hexane; isopropyl alcohol / 30 °C / Resolution of racemate

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

5.2: 0.33 h / 20 °C

6.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; borane-THF; ethanol; water; hydrogen bromide; sodium hydride; sodium hydroxide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 1207436-33-6
4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol / 2 h / Reflux

2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3.1: hydrogen bromide; water / 5 h / Reflux

4.1: sodium hydroxide / water

4.2: 20 h / 20 °C

4.3: pH Ca_. 3

5.1: borane-THF / tetrahydrofuran / 20 - 70 °C

6.1: CHIRALPAK AD / hexane; isopropyl alcohol / 30 °C / Resolution of racemate

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

7.2: 0.33 h / 20 °C

8.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; borane-THF; ethanol; water; hydrogen bromide; sodium methylate; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1016/j.bmc.2013.05.025