(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

Base Information

Chemical Name:(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide
CAS No.:1207438-51-4
Molecular Formula:BrH*C₁₃H₁₅Cl₂NO₂
Molecular Weight:369.086
Hs Code.:

Synonyms:(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

Chemical Property:

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Technology Process of (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

There total 4 articles about (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

Guidance literature:: With water; hydrogen bromide; for 5h; Reflux;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3: hydrogen bromide; water / 5 h / Reflux

With sodium tetrahydroborate; water; hydrogen bromide; sodium methylate; In methanol;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3: hydrogen bromide; water / 5 h / Reflux

With sodium tetrahydroborate; water; hydrogen bromide; sodium methylate; In methanol;
DOI:10.1016/j.bmc.2013.05.025