1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

Base Information

Chemical Name:1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide
CAS No.:1542706-80-8
Molecular Formula:C₂₆H₂₅N₅O₂
Molecular Weight:439.517
Hs Code.:

Synonyms:1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

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Chemical Property of 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

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Technology Process of 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

There total 9 articles about 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1542712-01-5
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carbonitrile

: 1542706-80-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

Guidance literature:: With water; urea hydrogen peroxide adduct; potassium carbonate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 134302-07-1
tert-butyl 3-cyclopropyl-3-oxopropanoate

: 1542706-80-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl acetamide / 4 h / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: sodium dithionite; sodium hydrogencarbonate; water / 1,4-dioxane / 0 - 20 °C

3.2: 2 h / 0 - 100 °C / Inert atmosphere

4.1: urea hydrogen peroxide adduct; water; potassium carbonate / dimethyl sulfoxide / 20 °C

With sodium dithionite; water; urea hydrogen peroxide adduct; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 1542711-91-0
tert-butyl 2-(2-cyano-6-nitrophenyl)-3-cyclopropyl-3-oxopropanoate

: 1542706-80-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-cyclopropyl-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium dithionite; sodium hydrogencarbonate; water / 1,4-dioxane / 0 - 20 °C

2.2: 2 h / 0 - 100 °C / Inert atmosphere

3.1: urea hydrogen peroxide adduct; water; potassium carbonate / dimethyl sulfoxide / 20 °C

With sodium dithionite; water; urea hydrogen peroxide adduct; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;