(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Base Information

Chemical Name:(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol
CAS No.:1376607-48-5
Molecular Formula:C₂₀H₂₉ClN₄O₂
Molecular Weight:392.929
Hs Code.:

Synonyms:(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

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Chemical Property of (3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

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Technology Process of (3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

There total 3 articles about (3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376607-46-3
{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

: 1376607-48-5
(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Guidance literature:: {4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol; With methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In 1,4-dioxane; methanol; water; Saturated solution;

Reference yield:

: 1376607-31-6
methyl 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate

: 1376607-48-5
(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 5.5 h / 20 °C

2.1: lithium borohydride; methanol / tetrahydrofuran / 4.5 h / 60 °C / Reflux

3.1: methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 4 h / 20 °C

3.2: 2 h / 20 °C

3.3: Saturated solution

With methanol; lithium borohydride; methanesulfonyl chloride; triethylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: methyl 4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate

: 1376607-48-5
(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium borohydride; methanol / tetrahydrofuran / 4.5 h / 60 °C / Reflux

2.1: methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 4 h / 20 °C

2.2: 2 h / 20 °C

2.3: Saturated solution

With methanol; lithium borohydride; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran;