{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

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Chemical Name:{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol
CAS No.:1376607-46-3
Molecular Formula:C₃₂H₅₈N₄O₃Si₂
Molecular Weight:603.009
Hs Code.:

{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

Synonyms:{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

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Chemical Property of {4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

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Technology Process of {4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

There total 2 articles about {4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate

: 1376607-46-3
{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

Guidance literature:: methyl 4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate; With methanol; lithium borohydride; In tetrahydrofuran; at 60 ℃; for 4.5h; Reflux;

With ammonium chloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1376607-31-6
methyl 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzoate

: 1376607-46-3
{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 5.5 h / 20 °C

2: lithium borohydride; methanol / tetrahydrofuran / 4.5 h / 60 °C / Reflux

With methanol; lithium borohydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1376607-46-3
{4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol

: 1376607-48-5
(3S)-3-({2-amino-5-[4-(chloromethyl)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)hexan-1-ol

Guidance literature:: {4-[(2-{[tert-butyl(dimethyl)silyl]amino}-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenyl}methanol; With methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In 1,4-dioxane; methanol; water; Saturated solution;