(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

Base Information

Chemical Name:(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole
CAS No.:417704-47-3
Molecular Formula:C₂₉H₄₅N₇O₆
Molecular Weight:587.72
Hs Code.:

Synonyms:(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

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Chemical Property of (2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

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Technology Process of (2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

There total 6 articles about (2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: methyl (S)-2-((2S,3S)-2-amino-3-methylpentanoylamino)-3-methylbutyrate hydrochloride

: 403616-78-4
(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-(carboxymethyl)-1H-tetrazole

: 417704-47-3
(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 417704-47-3
(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / H₂ / 10 percent Pd/C / methanol / 5 h / 20 °C / 760 Torr

2: 75 percent / EDCI; HOBt; DIPEA / dimethylformamide / 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 15196-02-8
(S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone

: 417704-47-3
(2S)-5-[2-(tert-butyloxycarbonylamino)-3-phenylpropyl]-1-[(methyl L-valinyl-L-isoleucinylcarbonyl)methyl]-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N / acetonitrile / 24 h / Irradiation

2: PCl₅; quinoline / CHCl₃ / 2.5 h / 20 °C

3: 300 mg / hydrazoic acid / CHCl₃; benzene / 48 h / 20 °C

4: 76 percent / H₂ / 10 percent Pd/C / methanol / 5 h / 20 °C / 760 Torr

5: 75 percent / EDCI; HOBt; DIPEA / dimethylformamide / 24 h / 20 °C

With quinoline; hydrogen azide; phosphorus pentachloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide; acetonitrile; benzene; 1: Wolff rearrangement;