1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Base Information

Chemical Name:1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol
CAS No.:1350714-47-4
Molecular Formula:C₃₁H₄₅N₃O₂
Molecular Weight:491.717
Hs Code.:

Synonyms:1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Suppliers and Price of 1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

There total 4 articles about 1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1350714-36-1
17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

: 1350714-47-4
1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: With methanol; potassium hydroxide; at 20 ℃; for 24h;
DOI:10.1039/c1ob06086d

Reference yield:

: 1350714-19-0
17β-acetoxy-1α-azido-5α-androstan-3-one

: 1350714-47-4
1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium borohydride; acetic acid / methanol / 3 h / pH 6 - 8

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

3: methanol; potassium hydroxide / 24 h / 20 °C

With methanol; copper(l) iodide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In methanol; toluene;
DOI:10.1039/c1ob06086d

Reference yield:

: 64-82-4,6656-41-3,21507-42-6,25615-33-2,54631-35-5,79732-37-9,97413-69-9
(5α,17β)-3-oxoandrost-1-en-17-yl acetate

: 1350714-47-4
1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; acetic acid / tetrahydrofuran; water / 24 h / 20 °C

2: potassium borohydride; acetic acid / methanol / 3 h / pH 6 - 8

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

4: methanol; potassium hydroxide / 24 h / 20 °C

With methanol; copper(l) iodide; sodium azide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; water; toluene; 1: Michael condensation;
DOI:10.1039/c1ob06086d