17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

Base Information

Chemical Name:17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol
CAS No.:1350714-36-1
Molecular Formula:C₃₃H₄₇N₃O₃
Molecular Weight:533.754
Hs Code.:

Synonyms:17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

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Chemical Property of 17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

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Technology Process of 17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

There total 3 articles about 17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 772-38-3
4-tert-Butylphenylacetylene

: 1350714-20-3
17β-acetoxy-1α-azido-5α-androstan-3β-ol

: 1350714-36-1
17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene; at 111 ℃; for 3h;
DOI:10.1039/c1ob06086d

Reference yield:

: 1350714-19-0
17β-acetoxy-1α-azido-5α-androstan-3-one

: 1350714-36-1
17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium borohydride; acetic acid / methanol / 3 h / pH 6 - 8

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

With copper(l) iodide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; toluene;
DOI:10.1039/c1ob06086d

Reference yield:

: 64-82-4,6656-41-3,21507-42-6,25615-33-2,54631-35-5,79732-37-9,97413-69-9
(5α,17β)-3-oxoandrost-1-en-17-yl acetate

: 1350714-36-1
17β-acetoxy-1α-[4'-(4''-tert-butylphenyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; acetic acid / tetrahydrofuran; water / 24 h / 20 °C

2: potassium borohydride; acetic acid / methanol / 3 h / pH 6 - 8

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

With copper(l) iodide; sodium azide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; toluene; 1: Michael condensation;
DOI:10.1039/c1ob06086d