(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester
CAS No.:121441-03-0
Molecular Formula:C₁₅H₁₈F₃NO₃
Molecular Weight:317.308
Hs Code.:

Synonyms:(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

There total 1 articles about (S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 121441-00-7
N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

: 121441-03-0
(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

Guidance literature:: With sodium hydroxide; potassium permanganate; sodium periodate; potassium carbonate; Yield given. Multistep reaction; 1.) t-BuOH, room temp., 1 h, 2.) Et₂O, room temp., 1 h;
DOI:10.1021/ja00198a048

Reference yield: 82.0%

: 121441-03-0
(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

: 15363-84-5
(S)-2-(benzylamino)-3-methylbutanoic acid

Guidance literature:: With sodium hydroxide; at 60 ℃; for 22h;
DOI:10.1021/ja00198a048

Reference yield:

: 121441-03-0
(S)-2-[Benzyl-(2,2,2-trifluoro-acetyl)-amino]-3-methyl-butyric acid methyl ester

: 17498-50-9,25616-14-2,31320-20-4
L-valine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 2N aq. NaOH / 22 h / 60 °C

2: 1.) 90percent HCOOH, 2.) conc. HCl / 1.) 10percent Pd-C / 1.) room temp., 63 h

With hydrogenchloride; sodium hydroxide; formic acid; palladium on activated charcoal;
DOI:10.1021/ja00198a048