N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

Base Information

Chemical Name:N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide
CAS No.:121441-00-7
Molecular Formula:C₁₈H₂₄F₃NO
Molecular Weight:327.39
Hs Code.:

Synonyms:N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

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Chemical Property of N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

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Technology Process of N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

There total 4 articles about N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 121440-85-5
(S,E)-N-benzyl-2,5-dimethyl-3-hex-4-enylamine

: 407-25-0
trifluoroacetic anhydride

: 121441-00-7
N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 17h; Ambient temperature;
DOI:10.1021/ja00198a048

Reference yield:

: 24502-08-7
(E)-4-methylpent-2-enal

: 121441-00-7
N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / diethyl ether / 2 h / Heating

2: 81 percent / pyridine, 4-(dimethylamino)pyridine / tetrahydrofuran / 8 h / Ambient temperature

3: (R)-(S)-BPPF-NMeCH(CH₂OH)2, Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 137 h / 40 °C

4: 92 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 17 h / Ambient temperature

With pyridine; dmap; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (R)-(S)-BPPF-NMeCH(CH₂OH)2; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00198a048

Reference yield:

: 121440-82-2
(E)-1-(1-methylethyl)-4-methyl-2-pentenyl ethyl carbonate

: 121441-00-7
N-Benzyl-2,2,2-trifluoro-N-((E)-(S)-1-isopropyl-4-methyl-pent-2-enyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: (R)-(S)-BPPF-NMeCH(CH₂OH)2, Pd₂(dba)3*CHCl₃ / tetrahydrofuran / 137 h / 40 °C

2: 92 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 17 h / Ambient temperature

With dmap; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (R)-(S)-BPPF-NMeCH(CH₂OH)2; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00198a048