3-phenylthiophene-2-carbaldehyde oxime

Base Information

• Chemical Name: 3-phenylthiophene-2-carbaldehyde oxime
• CAS No.: 157664-14-7
• Molecular Formula: C₁₁H₉NOS
• Molecular Weight: 203.265
• Mol file: 157664-14-7.mol

Synonyms:3-phenylthiophene-2-carbaldehyde oxime

Chemical Property of 3-phenylthiophene-2-carbaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-phenylthiophene-2-carbaldehyde oxime

There total 1 articles about 3-phenylthiophene-2-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-Phenyl-2-thiophenecarboxaldehyde (26170-85-4) → 3-phenylthiophene-2-carbaldehyde oxime (157664-14-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; Ambient temperature;

Reference yield: 94.0%

3-phenylthiophene-2-carbaldehyde oxime (157664-14-7) → 2-(aminomethyl)-3-phenylthiophene (157664-15-8)

Guidance literature:

With ammonium acetate; ammonia; zinc; In ethanol; Heating;

Reference yield:

3-phenylthiophene-2-carbaldehyde oxime (157664-14-7) → 6-phenyl-4H-thieno<2,3-d><2>benzazepine

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / Zn, aq. NH₄OAc, NH₃ / ethanol / Heating

2: 88 percent / Na₂CO₃ / CH₂Cl₂ / room temperature, 1 h, reflux, 30 min

3: SOCl₂ / dimethylformamide / 0.5 h / Ambient temperature

4: 69 percent / KOtBu / tetrahydrofuran / 0 deg C, 30 min, room temperature, 30 min

With thionyl chloride; potassium tert-butylate; ammonium acetate; ammonia; sodium carbonate; zinc; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-Phenyl-2-thiophenecarboxaldehyde

Downstream raw materials:

2-(aminomethyl)-3-phenylthiophene

2-benzamidomethyl-3-phenylthiophene

N-(3-phenyl-2-thienylmethyl)benzimidoyl chloride

Refernces