2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid

Base Information

• Chemical Name: 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid
• CAS No.: 1314864-11-3
• Molecular Formula: C₃₀H₂₈N₂O₅
• Molecular Weight: 496.563
• Mol file: 1314864-11-3.mol

Synonyms:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid

Chemical Property of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid

There total 10 articles about 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C37H34N2O5 (1314864-45-3) → 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid (1314864-11-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; for 12h;

DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

2,2-diphenyl-3-benzyloxy propionitrile (1314863-87-0) → 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid (1314864-11-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

2.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

4.2: 5 h / 90 °C

5.1: water; sodium hydroxide / methanol / 3 h / Reflux

6.1: potassium carbonate / water; N,N-dimethyl-formamide / 8 h

7.1: pyridine / 5 h / Reflux

8.1: palladium 10% on activated carbon; hydrogen / 12 h

With pyridine; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

2,2-diphenyl-3-benzyloxy propylaldehyde (1314863-88-1) → 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-[(3-methyl benzoyl)oxy] butyric acid (1314864-11-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

1.2: 20 °C

2.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

3.2: 5 h / 90 °C

4.1: water; sodium hydroxide / methanol / 3 h / Reflux

5.1: potassium carbonate / water; N,N-dimethyl-formamide / 8 h

6.1: pyridine / 5 h / Reflux

7.1: palladium 10% on activated carbon; hydrogen / 12 h

With pyridine; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.05.034

upstream raw materials:

2,2-diphenyl-3-benzyloxy propionitrile

2,2-diphenyl-3-benzyloxy propylaldehyde

2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyrrolactone