4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Base Information

Chemical Name:4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate
CAS No.:1481640-44-1
Molecular Formula:C₂₆H₁₉ClF₄N₂O₃
Molecular Weight:518.895
Hs Code.:

Synonyms:4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

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Chemical Property of 4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

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Technology Process of 4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

There total 6 articles about 4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1481640-58-7
4-methylbenzyl 7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-6-nitro-4-oxo-1,4-dihydro-3-quinolinecarboxylate

: 1481640-44-1
4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: With water; iron; sodium chloride; In N,N-dimethyl-formamide; at 150 ℃; for 24h;
DOI:10.1021/jm401362f

Reference yield:

: 148926-94-7
ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid

: 1481640-44-1
4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; diethyl ether / 0.08 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3: hydrogenchloride / water / 2.17 h / 120 °C / 11251.1 Torr / Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

5: sodium chloride; iron; water / N,N-dimethyl-formamide / 24 h / 150 °C

With hydrogenchloride; water; iron; potassium carbonate; sodium chloride; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f

Reference yield:

: 1481640-51-0
ethyl 2-(2,4-dichloro-5-nitrobenzoyl)-3-{[2-fluoro-4-(trifluoromethyl)benzyl]amino}acrylate

: 1481640-44-1
4-methylbenzyl 6-amino-7-chloro-1-[2-fluoro-4-(trifluoromethyl)benzyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2: hydrogenchloride / water / 2.17 h / 120 °C / 11251.1 Torr / Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

4: sodium chloride; iron; water / N,N-dimethyl-formamide / 24 h / 150 °C

With hydrogenchloride; water; iron; potassium carbonate; sodium chloride; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm401362f