trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

Base Information

Chemical Name:trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate
CAS No.:945999-95-1
Molecular Formula:C₂₅H₃₆N₄O₃
Molecular Weight:440.586
Hs Code.:

Synonyms:trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

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Chemical Property of trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

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Technology Process of trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

There total 6 articles about trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1072-97-5
5-bromo-2-pyridylamine

: 945996-91-8
trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid

: 945999-95-1
trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

Guidance literature:: 5-bromo-2-pyridylamine; trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid; With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 20 - 105 ℃; for 3.25 - 6.25h;

With hydrogenchloride; In ethanol; water; toluene;

With sodium hydrogencarbonate; In water; pH=9;

Reference yield:

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945999-95-1
trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran; methanol; toluene / 4 h / 20 °C

1.2: 1 h

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3.25 - 6.25 h / 20 - 105 °C

2.3: pH 9

With caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 15803-59-5,1932261-28-3,38362-02-6
(1r,4r)-N¹-methylcyclohexane-1,4-diamine

: 945999-95-1
trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzaldehyde / toluene / 6 h / Heating / reflux

1.2: 3.25 h / 20 °C

2.1: acetic acid / tetrahydrofuran; methanol; toluene / 4 h / 20 °C

2.2: 1 h

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3.25 - 6.25 h / 20 - 105 °C

3.3: pH 9

With caesium carbonate; benzaldehyde; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; toluene; 3.1: Suzuki Coupling;