C₃₇H₄₈N₂O₇S₂Si

Base Information

• Chemical Name: C₃₇H₄₈N₂O₇S₂Si
• CAS No.: 1565836-73-8
• Molecular Formula: C₃₇H₄₈N₂O₇S₂Si
• Molecular Weight: 725.015
• Mol file: 1565836-73-8.mol

Synonyms:C₃₇H₄₈N₂O₇S₂Si

Chemical Property of C₃₇H₄₈N₂O₇S₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₃₇H₄₈N₂O₇S₂Si

There total 9 articles about C₃₇H₄₈N₂O₇S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

carbon disulfide (75-15-0,12122-00-8) + C35H46N2O7Si (1565836-72-7) + methyl iodide (74-88-4) → C37H48N2O7S2Si (1565836-73-8)

Guidance literature:

C₃₅H₄₆N₂O₇Si; With 1H-imidazole; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃;

carbon disulfide; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; for 1h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; for 1h;

DOI:10.1021/ja500548e

Reference yield: 90.0%

carbon disulfide (75-15-0,12122-00-8) + C27H40N2O5Si + methyl iodide (74-88-4) → C37H48N2O7S2Si (1565836-73-8)

Guidance literature:

With 1H-imidazole; sodium hydride; In tetrahydrofuran; at 25 ℃;

DOI:10.1021/acs.joc.0c02493

Reference yield:

6-(tert-butyldimethylsilyloxy)-4-methylenehexanoic acid (1214750-03-4) → C37H48N2O7S2Si (1565836-73-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap

2.1: 1,2-dichloro-benzene / 230 °C

3.1: acetic acid; sodium cyanoborohydride / isopropyl alcohol / 16 h / 25 °C

4.1: hydrogen

5.1: ChiralCel OD column / isopropyl alcohol; hexane / Resolution of racemate

6.1: 1H-imidazole; sodium hydride / tetrahydrofuran; mineral oil / 0 - 25 °C

6.2: 1 h / 0 - 25 °C

6.3: 1 h / 0 - 25 °C

With 1H-imidazole; dmap; hydrogen; sodium hydride; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; hexane; 1,2-dichloro-benzene; isopropyl alcohol; mineral oil;

DOI:10.1021/ja500548e

upstream raw materials:

carbon disulfide

C₃₅H₄₆N₂O₇Si

methyl iodide

6-(tert-butyldimethylsilyloxy)-4-methylenehexanoic acid

Downstream raw materials:

C₃₅H₄₂N₂O₆Si

C₃₅H₄₄N₂O₅Si

C₂₉H₃₀N₂O₅

C₂₉H₂₉IN₂O₄