ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate
CAS No.:177847-76-6
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

There total 5 articles about ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 610-96-8
methyl chlorobenzoate

: 177846-38-7
5-(4-Bromo-benzyl)-3-isopropyl-1-propyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 177847-76-6
ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

Guidance literature:: With pyridine; triphenylphosphine; nickel dichloride; zinc; at 80 ℃; for 5h;
DOI:10.1021/jm9604383

Reference yield: 53.0%

: 177847-76-6
ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

Guidance literature:

Reference yield:

: 37859-24-8
2-(4-bromophenyl)acetyl chloride

: 177847-76-6
ethyl 3-isopropyl-5-[[2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl]-1-propyl-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Na / 1.) Et₂O, RT, overnight, 2.) Et₂O, a) RT, overnight, b) reflux, 1 h

2: NH₂NH₂*H₂O, AcOH / 18 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, 20 deg C, 18 h

4: 53 percent / NiCl₂, PPh₃, pyridine, Zn / 5 h / 80 °C

With pyridine; sodium; sodium hydride; hydrazine hydrate; acetic acid; triphenylphosphine; nickel dichloride; zinc;
DOI:10.1021/jm9604383