(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

Base Information

Chemical Name:(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester
CAS No.:1011242-73-1
Molecular Formula:C₄₈H₇₉Br₂O₁₄PSi
Molecular Weight:1099.01
Hs Code.:

(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

Synonyms:(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

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Chemical Property of (1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

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Technology Process of (1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

There total 1 articles about (1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3095-95-2
diethylphosphonoacetic acid

: 1011243-10-9
(3S,7S,8R,10E,12E,15S,16R)-18,18-dibromo-16-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-7-(4-methoxy-benzyloxy)-8-methyl-15-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-octadeca-10,12,17-trien-9-one

: 1011242-73-1
(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl iodide; In dichloromethane; at 23 ℃; for 2h;
DOI:10.1021/jo7024515

Reference yield: 63.0%

: 1011242-73-1
(1S,5S,6R,8E,10E,13S,14R)-(diethoxyphosphoryl)acetic acid 16,16-dibromo-14-(tert-butyl-dimethyl-silyloxy)-1-ethyl-5-(4-methoxybenzyloxy)-6-methyl-13-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-hexadeca-8,10,15-trienyl ester

: 185909-51-7
(E)-3-hydroxyprop-1-enylboronic acid

: 1011243-11-0
C₅₁H₈₄BrO₁₅PSi

Guidance literature:: With Ti₂CO₃; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 23 ℃; for 2h;
DOI:10.1021/jo7024515