(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

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Chemical Name:(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester
CAS No.:197159-43-6
Molecular Formula:C₂₄H₃₃N₃O₄S
Molecular Weight:459.61
Hs Code.:

Synonyms:(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

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Chemical Property of (S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

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Technology Process of (S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

There total 11 articles about (S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 53114-57-1
S-methylisothiourea hydrochloride

: 197159-27-6
(S)-2-tert-butoxycarbonylamino-5-oxo-7-phenylhept-6-ynoic acid tert-butyl ester

: 197159-43-6
(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

Guidance literature:: With sodium carbonate; In acetonitrile; Heating;
DOI:10.1039/a704526c

Reference yield: 79.0%

: 867-44-7,147895-43-0
S-Methylisothiourea sulfate

: 197159-27-6
(S)-2-tert-butoxycarbonylamino-5-oxo-7-phenylhept-6-ynoic acid tert-butyl ester

: 197159-43-6
(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

Guidance literature:: With water; sodium carbonate; In ethyl acetate; for 2h; Heating;
DOI:10.1039/a806741d

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid tert-butyl ester

: 197159-43-6
(S)-α-tert-butoxycarbonylamino-γ-(2-methylthio-6-phenylpyrimidin-4-yl)butyric acid α-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran; dimethylformamide / 1.) -15 deg C, 30 min, 2.) r.t., 12 h

2: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min; -78 deg C to r.t., 2 h

3: 79 percent / Na₂CO₃, H₂O / ethyl acetate / 2 h / Heating

With n-butyllithium; water; sodium carbonate; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/a806741d