4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

Base Information

Chemical Name:4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine
CAS No.:862183-13-9
Molecular Formula:C₂₃H₂₆BrN₃O₃
Molecular Weight:472.382
Hs Code.:

Synonyms:4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

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Chemical Property of 4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

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Technology Process of 4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

There total 10 articles about 4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 106-41-2
4-bromo-phenol

: 142611-36-7
(4S,4'S)-2,2'-(4-chloropyridine-2,6-diyl)bis(4-isopropyl-4,4-dihydrooxazole)

: 862183-13-9
4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 7h;
DOI:10.1021/jo050504l

Reference yield: 75.0%

: 106-41-2
4-bromo-phenol

: 477351-96-5
4-bromo-2,6-bis[(S)-4-isopropyloxazolin-2-yl]pyridine

: 862183-13-9
4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 7h;
DOI:10.1021/jo050504l

Reference yield:

: 499-51-4
Chelidamic acid

: 862183-13-9
4-(4-Bromo-phenoxy)-2,6-bis-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / PCl₅ / chlorobenzene / 14 h / Heating

2: 95 percent / SOCl₂ / chlorobenzene / 3.5 h / Heating

3: 80 percent / NEt₃ / CH₂Cl₂ / 24 h / 20 °C

4: 70 percent / SOCl₂ / CHCl₃ / 1.5 h / Heating

5: 70 percent / NaH / tetrahydrofuran / 0.75 h / 0 °C

6: 75 percent / K₂CO₃ / dimethylformamide / 7 h / 100 °C

With thionyl chloride; phosphorus pentachloride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jo050504l