4-Chloropyridine-2,6-dicarbonyl dichloride

Base Information

• Chemical Name: 4-Chloropyridine-2,6-dicarbonyl dichloride
• CAS No.: 71022-75-8
• Molecular Formula: C7H2Cl3NO2
• Molecular Weight: 238.457
• DSSTox Substance ID: DTXSID20509621
• Nikkaji Number: J1.311.584B
• Wikidata: Q82367340
• Mol file: 71022-75-8.mol

Synonyms:71022-75-8;4-Chloropyridine-2,6-dicarbonyl dichloride;4-Chloropyridine-2,6-dicarbonyl chloride;2,6-Pyridinedicarbonyl dichloride, 4-chloro-;4-chloropyridine-2,6-dicarboyl dichloride;SCHEMBL5375358;DTXSID20509621;AKOS015848400;4-Chloropyridine-2,6-dicarbonyldichloride;4-chloro-pyridine-2,6-dicarbonyl dichloride;FT-0747672;J-515188

Chemical Property of 4-Chloropyridine-2,6-dicarbonyl dichloride

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 236.915111
• Heavy Atom Count: 13
• Complexity: 212

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1C(=O)Cl)C(=O)Cl)Cl

Technology Process of 4-Chloropyridine-2,6-dicarbonyl dichloride

There total 10 articles about 4-Chloropyridine-2,6-dicarbonyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chelidamic acid (138-60-3) → 4-chloropyridine-2,6-dicarbonyl dichloride (71022-75-8)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1002/anie.201103716

Reference yield: 95.0%

4-chloro-2,6-pyridinedicarboxylic acid (4722-94-5) → 4-chloropyridine-2,6-dicarbonyl dichloride (71022-75-8)

Guidance literature:

With thionyl chloride; In chlorobenzene; for 3.5h; Heating;

DOI:10.1021/jo050504l

Reference yield: 91.0%

Chelidamic acid (499-51-4) → 4-chloropyridine-2,6-dicarbonyl dichloride (71022-75-8)

Guidance literature:

With Vilsmeier reagent; triethylamine; N,N-dimethyl-formamide; In acetonitrile; at 75 ℃; for 0.95h; under 5171.62 Torr;

DOI:10.1055/s-0031-1289676

upstream raw materials:

1-methyl-4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid

1-ethyl-4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid

4-chloro-2,6-pyridinedicarboxylic acid

Chelidamic acid

Downstream raw materials:

dimethyl 4-chloro-2,6-pyridinedicarboxylate

4-chloro-pyridine-2,6-dicarboxylic acid-dianilide

4-chloro-2,6-pyridinedicarboxylic acid

acide 4-ethoxy-2,6-pyridinedicarboxylique