(4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide

Base Information

• Chemical Name: (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide
• CAS No.: 612837-24-8
• Molecular Formula: C₃₀H₄₃N₃O₃
• Molecular Weight: 493.69

Synonyms:(4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide

Chemical Property of (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide

Chemical Property:

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Technology Process of (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide

There total 4 articles about (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[(4S,5S)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester (612837-13-5) → (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide (612837-24-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.233333h;

DOI:10.1016/S0040-4020(03)00857-3

Reference yield:

4-methoxybenzyl isocyanate (56651-60-6) → (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide (612837-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.3 mg / tetrahydrofuran / 2 h

2: 90 percent / TFA / CH₂Cl₂ / 0.23 h / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(03)00857-3

Reference yield:

((4S,5S)-5-Isobutoxy-azepan-4-yl)-((E)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester → (4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide (612837-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75.3 mg / tetrahydrofuran / 2 h

2: 90 percent / TFA / CH₂Cl₂ / 0.23 h / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(03)00857-3

upstream raw materials:

[(4S,5S)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

4-methoxybenzyl isocyanate

Downstream raw materials:

(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

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