(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

Base Information

Chemical Name:(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide
CAS No.:612837-14-6
Molecular Formula:C₃₁H₄₅N₃O₃
Molecular Weight:507.717
Hs Code.:

Synonyms:(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

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Chemical Property of (4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

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Technology Process of (4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

There total 5 articles about (4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 612837-24-8
(4S,5S)-4-Isobutoxy-5-((E)-(R)-2-methyl-4-phenyl-but-3-enylamino)-azepane-1-carboxylic acid 4-methoxy-benzylamide

: 612837-14-6
(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 16h; pH=6 - 7;
DOI:10.1016/S0040-4020(03)00857-3

Reference yield:

: 56651-60-6
4-methoxybenzyl isocyanate

: 612837-14-6
(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75.3 mg / tetrahydrofuran / 2 h

2: 90 percent / TFA / CH₂Cl₂ / 0.23 h / 20 °C

3: 74 percent / 4 Angstroem molecular sieves; NaBH₃CN; glacial AcOH / methanol; H₂O / 16 h / 20 °C / pH 6 - 7

With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(03)00857-3

Reference yield:

: ((4S,5S)-5-Isobutoxy-azepan-4-yl)-((E)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

: 612837-14-6
(4S,5S)-4-Isobutoxy-5-[methyl-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-amino]-azepane-1-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75.3 mg / tetrahydrofuran / 2 h

2: 90 percent / TFA / CH₂Cl₂ / 0.23 h / 20 °C

3: 74 percent / 4 Angstroem molecular sieves; NaBH₃CN; glacial AcOH / methanol; H₂O / 16 h / 20 °C / pH 6 - 7

With 4 A molecular sieve; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(03)00857-3