2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione

Base Information

• Chemical Name: 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione
• CAS No.: 1056472-35-5
• Molecular Formula: C₂₆H₂₀N₄O₆
• Molecular Weight: 484.468
• Mol file: 1056472-35-5.mol

Synonyms:2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione

Chemical Property of 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione

There total 2 articles about 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione (1056472-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / PPh₃, diethyl azidodicarboxylate / dimethylformamide / a) from 0 deg C to RT, 1 h, b) RT, 30 min

2: 1.) MeMgCO₃, CO₂ / 1.) DMF, 1.5 h, 2.) DMF, 110 deg C, 3 h

With carbon dioxide; MeMgCO₃; triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00018a016

Reference yield:

N-(3-Bromomethylphenyl)phthalimide (129747-78-0) + 1-<2-(4-nitrophenyl)ethyl>imidazolidine-2,5-dione (165605-28-7) → 2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione (1056472-35-5)

Guidance literature:

With carbon dioxide; MeMgCO₃; Multistep reaction; 1.) DMF, 1.5 h, 2.) DMF, 110 deg C, 3 h;

DOI:10.1021/jm00018a016

Reference yield:

2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione (1056472-35-5) → N-(3-{1-[2-(4-Amino-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-methanesulfonamide; hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 3 h / Heating

2: pyridine / 2 h / 0 °C

3: H₂, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate

With pyridine; hydrogenchloride; hydrogen; hydrazine hydrate; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00018a016

upstream raw materials:

N-(3-Bromomethylphenyl)phthalimide

1-<2-(4-nitrophenyl)ethyl>imidazolidine-2,5-dione

2-(4-nitrophenyl)ethanol

Downstream raw materials:

5-(3-Amino-benzyl)-3-[2-(4-nitro-phenyl)-ethyl]-imidazolidine-2,4-dione

N-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-acetamide

N-[3-(1-{2-[3-(2-Amino-ethyl)-1H-indol-5-yl]-ethyl}-2,5-dioxo-imidazolidin-4-ylmethyl)-phenyl]-acetamide

N-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-methanesulfonamide