N-(3-bromomethylphenyl)phthalimide

Base Information

• Chemical Name: N-(3-bromomethylphenyl)phthalimide
• CAS No.: 129747-78-0
• Molecular Formula: C15H10BrNO2
• Molecular Weight: 316.154
• NSC Number: 338435
• DSSTox Substance ID: DTXSID501217388
• Nikkaji Number: J943.974I
• Mol file: 129747-78-0.mol

Synonyms:NSC338435;SCHEMBL9454327;DTXSID501217388;N-(3-bromomethylphenyl)phthalimide;N-[3-(Bromomethyl)phenyl]phthalimide;NSC-338435;2-[3-(Bromomethyl)phenyl]-1H-isoindole-1,3(2H)-dione;129747-78-0

Chemical Property of N-(3-bromomethylphenyl)phthalimide

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 314.98949
• Heavy Atom Count: 19
• Complexity: 360

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)C3=CC=CC(=C3)CBr

Technology Process of N-(3-bromomethylphenyl)phthalimide

There total 2 articles about N-(3-bromomethylphenyl)phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(3-(hydroxymethyl)phenyl)isoindoline-1,3-dione (92789-55-4) → N-(3-Bromomethylphenyl)phthalimide (129747-78-0)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at -5 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ic301506x

Reference yield:

N-(3-methylphenyl)phthalimide (2314-76-3) → N-(3-Bromomethylphenyl)phthalimide (129747-78-0)

Guidance literature:

With N-Bromosuccinimide;

DOI:10.1016/S0040-4039(98)00110-5

Reference yield: 72.0%

N-(3-methylphenyl)phthalimide (2314-76-3) + N-(3-Bromomethylphenyl)phthalimide (129747-78-0) + (E)-N-ethyl-6,6-di-methyl-2-hepten-4-ynylamine hydrochloride → (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-phthalimidobenzylamine

Guidance literature:

With N-Bromosuccinimide; potassium carbonate; In N-methyl-acetamide; tetrachloromethane;

upstream raw materials:

N-(3-methylphenyl)phthalimide

2-(3-(hydroxymethyl)phenyl)isoindoline-1,3-dione

Downstream raw materials:

2-(3-{1-[2-(4-Nitro-phenyl)-ethyl]-2,5-dioxo-imidazolidin-4-ylmethyl}-phenyl)-isoindole-1,3-dione

3-N-phthalimidobenzaldehyde

({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester

C₂₆H₄₂N₆