2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione
CAS No.:1220951-02-9
Molecular Formula:C₂₁H₁₉Cl₂F₂N₃O₂
Molecular Weight:454.304
Hs Code.:

Synonyms:2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

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Chemical Property of 2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

There total 4 articles about 2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1220951-01-8
2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-oxopropyl)isoindoline-1,3-dione

: 1220951-02-9
2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 1220950-99-1
2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

: 1220951-02-9
2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; diethylamino-sulfur trifluoride; dimethyl sulfoxide; triethylamine; In dichloromethane;

Reference yield:

: 119532-26-2,864512-47-0
1-(2,3-dichlorophenyl)-piperazine hydrochloride

: 1220951-02-9
2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 80 °C / Inert atmosphere

2: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -60 - 20 °C / Inert atmosphere

3: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; diethylamino-sulfur trifluoride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;