2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

Base Information

• Chemical Name: 2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione
• CAS No.: 1220950-99-1
• Molecular Formula: C₂₁H₂₁Cl₂N₃O₃
• Molecular Weight: 434.322

Synonyms:2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

Chemical Property of 2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

There total 1 articles about 2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2,3-dichlorophenyl)-piperazine hydrochloride (119532-26-2,864512-47-0) + 2-oxiranylmethylisoindole-1,3-dione (5455-98-1) → 2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione (1220950-99-1)

Guidance literature:

With triethylamine; In isopropyl alcohol; at 100 ℃; for 1.5h; Microwave irradiation;

Reference yield: 95.0%

2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione (1220950-99-1) → 1-amino-3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propan-2-ol dihydrochloride

Guidance literature:

2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione; With hydrazine hydrate; In ethanol; at 20 - 80 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; Inert atmosphere;

DOI:10.1021/jm200682b

Reference yield: 43.0%

2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione (1220950-99-1) → 2-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-fluoropropyl]isoindoline-1,3-dione

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -8 - 20 ℃; for 24h;

upstream raw materials:

1-(2,3-dichlorophenyl)-piperazine hydrochloride

2-oxiranylmethylisoindole-1,3-dione

Downstream raw materials:

1-amino-3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propan-2-ol

2-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2,2-difluoropropyl)isoindoline-1,3-dione

N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-hydroxypropyl)-2,5-dimethyl-1-phenyl-1H-imidazole-4-carboxamide

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