2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

Base Information

Chemical Name:2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole
CAS No.:80429-42-1
Molecular Formula:C₂₇H₂₉F₃N₄
Molecular Weight:466.549
Hs Code.:

Synonyms:2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

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Chemical Property of 2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

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Technology Process of 2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

There total 6 articles about 2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80429-29-4
5-Bromo-1-(1-methylethyl)-2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1H-naphth[1,2-d]imidazole

: 80429-42-1
2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

Guidance literature:: With potassium hydroxide; hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol; Ambient temperature;
DOI:10.1016/0223-5234(87)90053-5

Reference yield:

: 5467-58-3
1-bromo-4-methoxynaphthalene

: 80429-42-1
2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / 99percent nitric acid, 96percent sulfuric acid / acetic anhydride / 0.17 h / -30 °C

2: 125 g / dimethylformamide / 1 h / Ambient temperature

3: 64 percent / 1,2-dichloro-ethane / 6 h / 120 °C

5: H₂, potassium hydroxide / 10percent palladium on carbon / 2-methoxy-ethanol / Ambient temperature

With potassium hydroxide; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In 2-methoxy-ethanol; acetic anhydride; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90053-5

Reference yield:

: 80429-47-6
4-bromo-1-methoxy-2-nitronaphthalene

: 80429-42-1
2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1-(1-methylethyl)-1H-naphth[1,2-d]-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 125 g / dimethylformamide / 1 h / Ambient temperature

2: 64 percent / 1,2-dichloro-ethane / 6 h / 120 °C

4: H₂, potassium hydroxide / 10percent palladium on carbon / 2-methoxy-ethanol / Ambient temperature

With potassium hydroxide; hydrogen; palladium on activated charcoal; In 2-methoxy-ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90053-5